Gene

Protein

OMIM

Estimated fraction of DCM

LMNA

Lamin A/C

150330

0.06

MYH7

β-Myosin heavy chain

160760

0.04

TNNT2

Cardiac troponin T

191045

0.03

RBM20

RNA binding protein 20

613171

0.02

TTN – truncating variants

Titin

188840

0.15 to 0.20

BAG3

BCL-associated athanogene 3

603883

0.03

SCN5A

Sodium channel

600163

0.02

TPM1

α-Tropomyosin

191010

<0.01

PLN

Phospholamban

172405

<0.01

TNNC1

Cardiac troponin C

191040

<0.01

TNNI3

Cardiac troponin I

191044

<0.01

EYA4

Eyes-absent 4

603550

?

MYPN

Myopalladin

608517

0.03

MYBPC3

Myosin-binding protein C

600958

0.02

MYH6

α-Myosin heavy chain

160710

0.04

TMPO

Thymopoietin

188380

<0.01

LAMA4

Laminin, alpha-4

600133

<0.01

VCL

Metavinculin

193065

<0.01

LDB3

Limb Domain-Binding 3

605906

<0.01

TCAP

Titin-cap or Telethonin

604488

<0.01

PSEN1

Presenilin 1

104311

<0.01

PSEN2

Presenilin 2

600759

<0.01

ACTN2

α-actinin-2

102573

<0.01

CRYAB

Alpha B crystalin

123590

<0.01

ABCC9

SUR2A

601439

<0.01

ACTC1

Cardiac actin

102540

<0.01

PDLIM3

PDZ LIM domain protein 3

605889

<0.01

ILK

Integrin-linked kinase

602366

<0.01

SGCD

δ-Sarcoglycan

601411

<0.01

DES

Desmin

125660

<0.01

CSRP3

Muscle LIM protein

600824

<0.01

ANKRD1

Ankyrin repeat domain-containing protein 1

609599

?

NEXN

Nexilin

613121

?

NEBL

Nebulette

605491

?

MURC

Muscle-restricted coiled-coil

No entry

Arrhythmogenic Right Ventricular Cardiomyopathy Genes Implicated in DCM

DSP

Desmoplakin

125647

?

PKP2

Plakophilin 2

602861

?

DSG2

Desmoglein 2

125671

?

X-linked Syndromic Genes in DCM

DMD

Dystrophin

300377

?

TAZ/G4.5

Tafazzin

300394

?