DCM Gene Table
Genes Implicated in Cause of DCM
Gene |
Protein |
OMIM |
Estimated fraction of DCM |
LMNA |
Lamin A/C |
0.06 |
|
MYH7 |
β-Myosin heavy chain |
0.04 |
|
TNNT2 |
Cardiac troponin T |
0.03 |
|
RBM20 |
RNA binding protein 20 |
0.02 |
|
TTN – truncating variants |
Titin |
0.15 to 0.20 |
|
BAG3 |
BCL-associated athanogene 3 |
0.03 |
|
SCN5A |
Sodium channel |
0.02 |
|
TPM1 |
α-Tropomyosin |
<0.01 |
|
PLN |
Phospholamban |
<0.01 |
|
TNNC1 |
Cardiac troponin C |
<0.01 |
|
TNNI3 |
Cardiac troponin I |
<0.01 |
|
EYA4 |
Eyes-absent 4 |
? |
|
MYPN |
Myopalladin |
0.03 |
|
MYBPC3 |
Myosin-binding protein C |
0.02 |
|
MYH6 |
α-Myosin heavy chain |
0.04 |
|
TMPO |
Thymopoietin |
<0.01 |
|
LAMA4 |
Laminin, alpha-4 |
<0.01 |
|
VCL |
Metavinculin |
<0.01 |
|
LDB3 |
Limb Domain-Binding 3 |
<0.01 |
|
TCAP |
Titin-cap or Telethonin |
<0.01 |
|
PSEN1 |
Presenilin 1 |
<0.01 |
|
PSEN2 |
Presenilin 2 |
<0.01 |
|
ACTN2 |
α-actinin-2 |
<0.01 |
|
CRYAB |
Alpha B crystalin |
<0.01 |
|
ABCC9 |
SUR2A |
<0.01 |
|
ACTC1 |
Cardiac actin |
<0.01 |
|
PDLIM3 |
PDZ LIM domain protein 3 |
<0.01 |
|
ILK |
Integrin-linked kinase |
<0.01 |
|
SGCD |
δ-Sarcoglycan |
<0.01 |
|
DES |
Desmin |
<0.01 |
|
CSRP3 |
Muscle LIM protein |
<0.01 |
|
ANKRD1 |
Ankyrin repeat domain-containing protein 1 |
? |
|
NEXN |
Nexilin |
? |
|
NEBL |
Nebulette |
? |
|
MURC |
Muscle-restricted coiled-coil |
No entry |
|
Arrhythmogenic Right Ventricular Cardiomyopathy Genes Implicated in DCM |
|||
DSP |
Desmoplakin |
? |
|
PKP2 |
Plakophilin 2 |
? |
|
DSG2 |
Desmoglein 2 |
? |
|
X-linked Syndromic Genes in DCM |
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DMD |
Dystrophin |
? |
|
TAZ/G4.5 |
Tafazzin |
? |